Frequently Asked Questions

Choose from the topics below to learn more about what’s important to you.

Top Side Effects and Safety Questions

Can NSAIDs cause heart attacks or high blood pressure?

All NSAIDs (nonsteroidal anti-inflammatory drugs), except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.

Ask your doctor if you should take Advil® if you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke.

Could I have an allergic reaction to Advil®?

Advil®/Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:

  • hives
  • facial swelling
  • asthma (wheezing)
  • shock
  • skin reddening
  • rash
  • blisters

If an allergic reaction occurs, stop use and seek medical help right away.

What are the long-term effects of taking Advil®?

Advil® has been effectively relieving pain for over 30 years. However, Advil® is only indicated for short-term use. You should talk to your doctor if your pain gets worse or last for more than 10 days, or if your fever gets worse or lasts for more than 3 days.

Is Advil® safe?

For more than 30 years, extensive consumer use and numerous clinical studies have shown that, ibuprofen, the active ingredient in Advil®, when used as directed, is a safe and effective OTC pain reliever and fever reducer.

Please refer to the full product labeling for additional safety information related to Advil®.

What are the side effects of taking Advil?

Over 30 years of studies and use have shown that Advil®, when used as directed, is safe and effective at relieving pain. As with all medicines however, some side effects may occur.

Before using Advil®, we recommend you read our warnings. Learn more about the side effects of Advil®.

Can Advil® be taken with other OTC medications, e.g. other pain relievers like Excedrin® or Aleve®, antibiotics, cold remedies like Sudafed® or Mucinex®, etc.?

Ask a doctor or pharmacist before use if you are taking any other drug. Advil® should not be taken with any other product containing ibuprofen (like Motrin®), naproxen (like Aleve® or Midol®), acetaminophen (like Tylenol®) or aspirin. If you’re not sure if it will interfere with your other medications, talk to your doctor or pharmacist first.

Will this product interact with my prescription medication?

If you have any condition that requires a prescription medication, talk with your doctor or pharmacist about using Advil®, or any other pain reliever.

Can Advil® be taken with nutritional supplements?

While Advil® can be taken with nutritional supplements, it’s recommended that you talk about any risks with your doctor or pharmacist before taking Advil® with nutritional supplements.

Can Advil® be taken with herbal supplements?

Since herbal supplements may contain complex formulations that can interact with medications, talk with your doctor or pharmacist before taking them with Advil®.

Is ibuprofen addictive? Will it cause withdrawal symptoms?

No. Advil® is not habit forming, and it does not demonstrate addictive properties. Studies show that ibuprofen affects the body (peripherally active), not the brain (not centrally active). Advil® is nonnarcotic.

Is Advil® bad for my liver?

When taken as directed, adverse effects on the liver are uncommon. Effects on the liver are rare but may include liver disorder, abnormal liver function, hepatitis and jaundice, and, they may occur at higher than recommended OTC doses.

Consult your doctor before taking Advil® if you have liver cirrhosis, or any other concerns about taking this product.

What effect will Advil® have on the kidneys?

When taken as directed, adverse effects of Advil® on the kidneys are not common. However, higher doses can produce adverse effects on the kidneys. Consult your doctor before taking Advil® if you are taking a diuretic, have kidney disease or have any other concerns.

Does Advil® cause ulcers?

While ibuprofen may cause ulcers, they’re usually the result of higher prescription doses or when administered for long periods of time. Studies have proven that when used as directed, Advil® is safe and effective.

If you have a history of stomach problems, such as heartburn, consult your doctor before using Advil®.

Can I take alcohol with Advil®?

We do not recommend that you take alcohol with Advil®. This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you have 3 or more alcoholic drinks every day while using this product.

Does Advil® make you sleepy?

Advil® does not contain any ingredients or antihistamines that would make you sleepy. If pain is keeping you awake at night and you want a medication that can help you fall asleep, learn more about Advil® PM.

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Pfizer Inc., PO Box 1043
Kings Mountain, NC 28086

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