Frequently Asked Questions

Choose from the topics below to learn more about what’s important to you.


What effect will Advil® have on the kidneys?

It’s uncommon for Advil® to harm the kidneys when it’s taken as directed. But higher doses or prolonged use can cause adverse effects. It’s also important to get clearance from your doctor if you are taking a diuretic, have kidney disease or have any other concerns.

Can Advil® be taken with vitamins and supplements?

Some vitamins and supplements contain ingredients that can interact with medications like Advil® (ibuprofen) so it’s best to talk to your doctor or pharmacist before taking them together.

Can I take Advil® if I'm on a CBD therapy?

Cannabidiol or CBD products are new to the market and not enough studies have been done to know how they interact with medications like Advil®. If you’re thinking about taking CBD it’s best to talk to your doctor before using it with another drug.

Can Advil® be taken with other OTC pain relievers like Excedrin® or Aleve®?

No. Do not take Advil® with other pain relievers that contain ibuprofen, acetaminophen, naproxen, or aspirin. To learn more about drug interactions, click here.

Can I take Advil® if I’m taking opioid medication?

It's best to talk to your doctor about combining Advil® with opioids since there's possibility for drug interaction.

It’s important to know that studies show that taking ibuprofen (Advil®) can reduce the amount of opioids needed for pain relief, and in some cases they’re even prescribed together.

Can I take Advil® with alcohol?

It’s best to not take Advil® with alcohol. Advil® and other NSAIDs can cause severe stomach bleeding, especially if taken at higher doses for long periods of time. Those chances increase if you have 3 or more alcoholic drinks a day while taking Advil®.

Can I take Advil® if I'm on aspirin therapy?

It’s best not to unless directed to do so by your doctor. Advil® and ibuprofen, its active ingredient, have potential to interfere with aspirin’s anti-blood clotting effect, reducing its ability protect your heart and prevent stroke.

Is Advil® Safe?

For more than 30 years, extensive consumer use and numerous clinical studies have shown that, ibuprofen, the active ingredient in Advil®, when used as directed, is a safe and effective OTC pain reliever and fever reducer.

Please refer to the full product labeling for additional safety information related to Advil®.

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Call a customer service representative toll-free at:
1-800-882-3845 (1-800-88-ADVIL)
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Pfizer Inc., PO Box 1043
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