Advil, Tylenol, or Motrin: Which is the best pain reliever for you?

When you’re not feeling well, some of your symptoms may be pain-related, such as backaches, headaches and muscle aches. There are plenty of products on the market and in your local stores that may claim to help relieve your pain, but some do a better job than others.1 The medicine in Advil is what doctors use most for their own aches and pains.
Learn how Advil products compare to other over-the-counter medications and products that claim to target the same symptoms. Use the comparison tool below to compare different Advil products to other pain relief brands to find out how Advil can relieve your pain.
![]() Advil Liqui-Gels4,5 |
![]() Tylenol Rapid Release6 |
|
---|---|---|
Clinically proven to work faster | ✔︎ | ✖︎ |
Clinically proven to last longer | ✔︎ | ✖︎ |
Targets pain at the source | ✔︎ |
✖︎ |
Headaches | ✔︎ |
✔︎ |
Reduces fever | ✔︎ |
✔︎ |
Back pain | ✔︎ |
✔︎ |
Muscle aches | ✔︎ |
✔︎ |
Toothaches | ✔︎ |
✔︎ |
Pains and Aches Due to Common Cold (combined cold and flu) | N/A |
N/A |
Contains a non-steroidal anti-inflammatory drug (NSAID) | ✔︎ |
✖︎ |
Available in minis | ✔︎ |
✖︎ |
Sugar free | N/A |
N/A |
Starts working in 16 minutes? | ✔︎ |
✔︎ |
First FDA-approved ibuprofen/acetaminophen combination | N/A |
N/A |
Clinical studies on drug combination | N/A |
N/A |
May decrease the benefit of Aspirin Heart Therapy | ✔︎ |
✖︎ |
Dosage | Adults and children 12 years and older:
|
2 caplets every 6 hours as needed, not to exceed 6 caplets in a 24-hour period. |
Dosage based on weight* | N/A |
N/A |
Dosage based on age | N/A |
N/A |
Safe for children under 12 years | Ask a doctor | Ask a doctor |
Safe for children under 2 years, or under 24 pounds | N/A |
N/A |
Gastrointestinal warning | This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:
|
✖︎ |
Cardiovascular warning | NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed. |
✖︎ |
Liver warning | Ask a doctor before use if you have liver cirrhosis |
Severe liver damage may occur if you take:
|
Allergy warning | Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:
If an allergic reaction occurs, stop use and seek medical help right away |
Acetaminophen may cause severe skin reactions. Symptoms may include:
If a skin reaction occurs, stop use and seek medical help right away. |
How Advil Beats Other Pain Relief Brands
Advil products are fast-acting and come in a variety of forms to provide easy digestion for you and your children. These products contain non-steroidal anti-inflammatory drugs (NSAIDs) that help relieve your pain, reduce pain at the source of inflammation, and temporarily reduce fever.14 Instead of combining different medications and OTC products, find one that works to relieve your symptoms. Use the relief finder tool to find the Advil product that targets your specific symptoms if you’re not sure which product is for you.
Source Citations:
1. Advil Dual Action. Advil. https://www.advil.com/our-products/advil-pain/advil-dual-action/. Accessed 04/12/2023.
2. Patient Resources: Advil Dual Action. Haleon Health Partner. https://www.haleonhealthpartner.com/en-us/patient-care-resources/patient-education-advil-faqs/. Accessed 03/28/2023.
3. Motrin Dual Action with Tylenol – acetaminophen and ibuprofen tablet, film coated. DailyMed. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f2ee9cf5-02b7-6612-e053-2995a90a90c4&version=1. Accessed 03/28/2023.
4. Advil Liqui-Gels. Haleon Health Partner. https://www.haleonhealthpartner.com/en-ca/pain-relief/brands/advil/products/liqui-gels/. Accessed 04/12/2023.
5. Advil Liqui-Gels. Advil. https://www.advil.com/content/dam/cf-consumer-healthcare/bp-advil-v2/en_US/pdf/LBL-00000029%20WEB%20READY%20ADVIL%20LIQUI-GELS%20(Version%2042).PDF. Accessed 04/12/2023.
6. Tylenol Extra Strength – acetaminophen tablet, coated. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1b164780-ec84-4187-8afa-6f8a0da550fc. Accessed 04/12/2023.
7. Children’s Advil. Haleon Health Partner. https://www.haleonhealthpartner.com/en-us/pain-relief/brands/advil/products/childrens-advil/. Accessed 04/12/2023.
8. Children’s Advil Suspension Sugar Free Berry. Advil. https://www.advil.com/our-products/childrens-advil/childrens-advil-suspension-sugar-free-dye-free-berry/. ccessed 03/28/2023.
9. Children’s Tylenol – acetaminophen suspension. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=333f6231-3778-4c1f-9558-2afddca22c86. Accessed 04/12/2023.
10. Children’s Tylenol – acetaminophen tablet, chewable. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9782fe86-d72a-4231-b1ba-d3f3b4ee49e3. Accessed 03/28/2023.
11. Children’s Tylenol – acetaminophen powder. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=79669930-f744-4bb1-8325-b75951489b64. Accessed 03/28/2023.
12. Advil Tablets. Haleon Health Partner. https://www.haleonhealthpartner.com/en-us/pain-relief/brands/advil/products/advil-tablets/. Accessed 03/28/2023.
13. Tylenol Extra Strength – acetaminophen tablet, film coated. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=59773893-09a8-47a2-943a-e9ea9da4458a. Accessed 04/12/2023.
14. NSAIDs. United Kingdom National Health Service. https://www.nhs.uk/conditions/nsaids/. Accessed 03/28/2023.